Age-dependent sex differences in cardiometabolic risk factors

Abstract Cardiometabolic diseases (CMDs) are a major cause of mortality worldwide, yet men and women present remarkable differences in disease prognosis, onset manifestation. Here we characterize how sex cardiometabolic risk factors vary with age by examining 45 phenotypes 6 lifestyle 146,021 participants the Dutch population cohort Lifelines. We show that 71% studied phenotypes. For 31% these phenotypes, phenotypic difference between sexes is dependent on age. CMD various patterns age-related differences, ranging from no for such as body mass index (BMI) to strong age-modified lipid levels. also identify influence sex- age-dependent manner. These results highlight importance taking into account when studying CMDs.